Scientific American - Mind & Brain

Mine Injuries Rise Right after Daylight Saving Time

Fri, 12 Mar 2010 13:30:08 EST

Don’t forget to move your clocks forward this weekend. And then don’t forget to be more careful in the days after you adjust your clocks. Because a recent study found that the hour of lost sleep was related to increased job-related injuries. Probably because sleepy workers were less alert. The work appeared last September in the Journal of Applied Psychology . [ see http://bit.ly/coie2b ] [More]

Consciousness-Raising: Kick-Starting the Brain's Dopamine System May Revive Some Vegetative Patients

Fri, 12 Mar 2010 13:23:00 EST

A drug targeting dopamine receptors might be able to "kick-start" an injured brain, enabling certain kinds of vegetative and minimally conscious patients to recover faster. [More]

Gene Target Beats Oil Remedy

Fri, 12 Mar 2010 09:00:00 EST

The 1992 tearjerker Lorenzo’s Oil told the true story of one family’s struggle to save their son from X-linked adrenoleukodystrophy (ALD), a deadly degenerative brain disease. Unfortunately, over the ensuing years, the oil of the film’s title, a dietary supplement, has not panned out as the cure many people hoped it would be. Now a paper in the November 2009 issue of Science suggests that the long-sought cure may come from gene therapy--a famously hyped approach to treatment that tragically caused the death of a teenage experimental subject in 1999.

Since then, however, researchers have continued to cautiously pursue gene therapy for certain disorders with known genetic origins. ALD, for instance, is caused by mutations in a gene called ABCD1, leading to unusually high levels of a type of fatty acid that damages the material insulating some neurons. It affects about one in 20,000 six- to eight-year-old boys, leading to death before adolescence. The main treatment is still bone marrow transplantation: a risky procedure that relies on finding a suitable donor, explains Patrick Aubourg, a neurologist at France’s INSERM research institute.

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MIND Reviews: The Other Brain

Fri, 12 Mar 2010 09:00:00 EST

The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science by R. Douglas Fields. [More]

Readers Respond on "A Path to Sustainable Energy by 2030"

Fri, 12 Mar 2010 08:00:00 EST

Winds of Change I found it surprising that in “ A Path to Sustainable Energy by 2030 ,” Mark Z. Jacobson and Mark A. Delucchi do not mention the effects of the suggested energy sources on climate. The authors propose to absorb about six terawatts of energy from about 60 terawatts available in the wind, or about 10 percent of its total energy. Because the winds, at least near the U.S., usually flow around highs or lows, where the speed and related Coriolis force tend to maintain the pressure difference, I can easily envision that absorbing the energy will change the rate at which the pressure centers collapse. How this would change the weather, I do not know, but it must make a change to give us some of the energy. Possibly, the weather change would be an improvement, but as a believer in Murphy’s Law, I would be surprised. About 100 years ago dumping garbage into the ocean was justified because the oceans were infinite compared to the effect, so no one calculated how much was allowable. Let’s be smarter this time! Why not do the calculations before we cause more problems? [More]

If Darwin were a sports psychologist: Evolution and athletics

Thu, 11 Mar 2010 18:19:00 EST

Arranged Marriages Can Be Real Love Connection

Thu, 11 Mar 2010 10:30:08 EST

Think arranged marriages are loveless? Not so, says psychologist Robert Epstein, a contributing editor for Scientific American MIND magazine. He spoke March 10 at the 92nd Street Y’s Tribeca site in New York City:

“And there’s even a study published in India [Usha Gupta and Pushpa Singh of the University of Rajasthan, 1982] but using an American love scale, called the Rubin Love Scale, that compared love in love marriages in India, because they have those, too, to love in arranged marriages. And in this particular study, love in the love marriages starts out very high. And then over time it decreases. That’s what all of our studies show. And in the arranged marriages--and this is true in my work, too--we see the love starting out relatively low. Because in some cases the people barely know each other, sometimes they’ve had a half an hour of contact in total before they got married. And then it increases gradually, surpasses the love in the love marriages at about five years. And 10 years out it’s twice as strong.”

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New Hope for Battling Brain Cancer (preview)

Thu, 11 Mar 2010 09:00:00 EST

In May 2006 Dwayne Berg woke up on a gurney in a Seattle emergency room, an IV in his arm and a team of doctors and nurses working him up. The last thing the 42-year-old financial executive could remember was running on a treadmill at his gym, part of his regular fitness regimen. He had suffered a seizure and tumbled off the machine, and although he had not hurt himself in the fall, doctors had asked for an MRI scan of his brain to see if they could find a cause for the seizure.

They did, and the news was not good: the scan showed a large mass in the left frontal lobe that turned out to be a malignant glioma, a brain cancer that is almost invariably fatal. Berg underwent standard treatment: an operation to remove the tumor, followed by chemotherapy and radiation to eradicate any cancer cells that might remain.

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Divining the Right Drug

Thu, 11 Mar 2010 09:00:00 EST

Imagine suffering from the crushing weight of major depression, then finally getting diagnosed and starting treatment with a drug--only to realize after two months that the medication, despite its unpleasant side effects, is not alleviating your depression. Unfortunately, this experience is far from rare: more than two thirds of patients with depression have no luck with the first medication they are prescribed and must also endure the withdrawal effects that come with discontinuing a drug before trying a new one. Finding the right treatment can prove a lengthy, painful process of trial and error. A new technology, however, may bypass this ordeal by gauging very early in a treatment regimen how well a drug is working based on the patient’s brain waves.

The technology, called quantitative electroencephalography (QEEG), measures a person’s brain-wave pattern with EEG and then compares it with a database of normal samples to detect abnormal function. In a study published in the September 2009 issue of the journal Psychiatry Research , scientists used QEEG to record brain activity in subjects with major depressive disorder before they began treatment, after one week on an antidepressant and after eight weeks on the drug--the period it takes such drugs to achieve full effect. Changes in the QEEG readout after just one week of medication predicted 74 percent of the time whether patients would experience either a recovery or a remission of symptoms by the end of eight weeks.

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Few Studies Compare the Efficacy of Medical Treatments

Wed, 10 Mar 2010 10:00:00 EST

The forward momentum of medical progress is manifest, it could be argued, in the $50 billion spent in 2008 on pharmaceutical research and development in the quest to bring new drugs to market. But little scientific or governmental infrastructure exists to ensure that each new treatment is actually an improvement over existing therapies--and to tease out what therapies are best for which patients. [More]

Why is talking with gestures easier than talking without them?

Wed, 10 Mar 2010 09:00:00 EST

Why is talking along with gestures so much easier than trying to talk without gesturing? -- Lionel Halvorsen, Cornith, Tex.

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Chimps Talk with Their Hands

Wed, 10 Mar 2010 09:00:00 EST

The origins of language have long been a mystery, but mounting evidence hints that our unique linguistic abilities could have evolved from gestural communication in our ancestors. Such gesturing may also explain why most people are right-handed.

Researchers at the Yerkes National Primate Research Center recently examined captive chimpanzees and found that most of them predominantly used their right hand when communicating with one another--for example, when greeting another chimp by extending an arm. The animals did not show this hand preference for noncommunicative actions, such as wiping their noses. Such lateralized hand use suggests that chimpanzees have a system in their left brain hemisphere that is coupled to the production of communicative gestures, says study author William Hopkins. The same cerebral hemisphere is host to most language functions in humans, which hints that an ancestral gestural system could have been the precursor for language, he says.

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End-of-Days Danger

Wed, 10 Mar 2010 08:00:00 EST

I don’t know how many e-mails I have received from children who are terrified that 2012 will somehow involve the end of life as we know it, all because of an unfounded fringe religious prophecy that has received mass-market exposure with the release of a recent Hollywood movie. I have tried to reassure those children (and not a few adults) that this date represents nothing more cosmically special than the year of the next presidential election.

Having said that, however, I just realized there might be a genuine connection between 2012 and an end-of-days menace!

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Belief in the Brain

Tue, 09 Mar 2010 09:00:00 EST

Religious belief may seem to be a unique psychological experience, but a growing body of research shows that thinking about religion is no different from thinking about secular things--at least from the standpoint of the brain. In the first imaging study to compare religious and nonreligious thoughts, evaluating the truth of either type of statement was found to involve the same regions of the brain.

Researchers at the University of California, Los Angeles, used functional MRI to evaluate brain activity in 15 devout Christians and 15 nonbelievers as the volunteers assessed the truth or falsity of a series of statements, some of which were religious (“angels exist”) and others nonreligious (“Alexander the Great was a very famous military ruler”). They found that when a subject believed a statement--whether it was religious or not--activity appeared in an area called the ventromedial prefrontal cortex, which is an area associated with emotions, rewards and self-representation.

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Scooting toward Oblivion

Tue, 09 Mar 2010 08:00:00 EST

There’s a story about a truck driver who passed the long, lonely hours in his big rig knitting sweaters. His hands thus otherwise occupied, he steered with his knees. A highway patrol officer noted this behavior and set out after the truck driver. As the cop got close, he commanded via his vehicle’s loudspeaker, “Pull over.” To which the trucker shouted back, “No, it’s a cardigan.”

Though not a bona fide law-enforcement officer myself, I sometimes act in loco centurion while on the road. I do this by sharing safety tips with distracted motorists, such as “Slow down!” or “Pick a lane!” or, my go-to line, “Get off the phone!”

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The Psychology of the Taboo Trade-Off

Tue, 09 Mar 2010 00:00:00 EST

Consider the classic hypothetical scenario: Your house is on fire and you can take only three things with you before the entire structure becomes engulfed in flames. What would you take? Laptops and external hard drives aside, people’s responses to this question differ wildly. This diversity results from people’s flexibility in ascribing unique value to objects ranging from a hand-scrawled note from a loved one to a threadbare t-shirt that others might consider worthless.

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Accents Trump Skin Color

Mon, 08 Mar 2010 09:00:00 EST

Children, like adults, use three visible cues--race, gender and age--to arrange their social world. They prefer to make friends with kids similar to them on these traits. New research shows that verbal accents may be equally important in guiding youngsters’ social decisions--in fact, accents may be even more important than race.

Working at Harvard University, developmental psychologist Katherine D. Kinzler and her colleagues first showed American five-year-olds photographs of different children paired with audio clips of voices and asked which ones they preferred as a friend: a child who spoke English, one who spoke French, or one who spoke English with a French accent. Even though the subjects understood the French-accented English, they were almost four times more likely to choose the native English speaker as a friend.

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Attention Shoppers: You Underestimated Your Bill

Mon, 08 Mar 2010 08:27:08 EST

So, they’re scanning your items at the grocery store, and when the last tomato gets bagged you’re stunned at the cost. How did you spend so much? Maybe those cherries were 12 bucks a pound. Or maybe you should have paid more attention to what you put in the wagon. Then again, maybe not. Because a new study in the Journal of Marketing [see http://tinyurl.com/yl5dbxg ] shows that the harder shoppers try to keep track of what they’re spending, the worse they actually do. [More]

Happy People Talk More Seriously

Sat, 06 Mar 2010 18:00:08 EST

[ Hear movie clip by clicking on audio podcast above. ]

That’s a scene from the 1968 movie The Party with Peter Sellers attempting small talk. And sometimes small talk can lead to interesting connections.

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Playing the Body Electric

Fri, 05 Mar 2010 09:00:00 EST

Each new generation of astronomers discovers that the universe is much bigger than their predecessors imagined. The same is also true of brain complexity. Every era’s most advanced technologies, when applied to the study of the brain, keep uncovering more layers of nested complexity, like a set of never ending Russian dolls. We now know that there are up to 1,000 different subtypes of nerve cells and supporting actors--the glia and astrocytes--within the nervous system. Each cell type is defined by its chemical constituents, neuronal morphology, synaptic architecture and input-output processing.

Different cell types are wired up in specific ways. For example, a deep layer 5 pyramidal neuron might snake its gossamer-thin output wire, the axon, to a subcortical target area while also extending a connection to an inhibitory local neuron. Understanding how the brain’s corticothalamic complex creates any one conscious sensation necessitates delineating these underlying circuits for the 100 billion cells in the brain.

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