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Scientific American

November 9, 2020

1 min read

Coronavirus Vaccine Is 90 Percent Effective in Large Trial, Pfizer Says

Genetic engineering could allow for speedy production as well

By Mark Fischetti & Jen Christiansen

Jen Christiansen

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Pfizer and BioNTech announced today that their experimental vaccine against the novel coronavirus is more than 90 percent effective in preventing the disease COVID-19, based on initial analysis of results from their large phase III trial. The two companies also report that no serious safety concerns have arisen thus far. To create the vaccine, researchers genetically engineered SARS-CoV-2 genes, captured their blueprint, embedded that blueprint into an RNA molecule in solution and injected the solution into the bodies of trial participants. The full method for this approach is outlined in the graphic below (light blue boxes), which originally appeared in the June 2020 issue of Scientific American.The trial’s data have not yet been submitted for peer-review publication. If the results hold up, Pfizer and BioNTech say they could manufacture large quantities of the genetically engineered vaccine quickly.

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Credit: Jen Christiansen

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Mark Fischetti has been a senior editor at Scientific American for 17 years and has covered sustainability issues, including climate, weather, environment, energy, food, water, biodiversity, population, and more. He assigns and edits feature articles, commentaries and news by journalists and scientists and also writes in those formats. He edits History, the magazine's department looking at science advances throughout time. He was founding managing editor of two spinoff magazines: Scientific American Mind and Scientific American Earth 3.0. His 2001 freelance article for the magazine, "Drowning New Orleans," predicted the widespread disaster that a storm like Hurricane Katrina would impose on the city. His video What Happens to Your Body after You Die?, has more than 12 million views on YouTube. Fischetti has written freelance articles for the New York Times, Sports Illustrated, Smithsonian, Technology Review, Fast Company, and many others. He co-authored the book Weaving the Web with Tim Berners-Lee, inventor of the World Wide Web, which tells the real story of how the Web was created. He also co-authored The New Killer Diseases with microbiologist Elinor Levy. Fischetti is a former managing editor of IEEE Spectrum Magazine and of Family Business Magazine. He has a physics degree and has twice served as the Attaway Fellow in Civic Culture at Centenary College of Louisiana, which awarded him an honorary doctorate. In 2021 he received the American Geophysical Union's Robert C. Cowen Award for Sustained Achievement in Science Journalism, which celebrates a career of outstanding reporting on the Earth and space sciences. He has appeared on NBC's Meet the Press, CNN, the History Channel, NPR News and many news radio stations. Follow Fischetti on X (formerly Twitter) @markfischetti

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Jen Christiansen is author of the book Building Science Graphics: An Illustrated Guide to Communicating Science through Diagrams and Visualizations (CRC Press) and senior graphics editor at Scientific American, where she art directs and produces illustrated explanatory diagrams and data visualizations. In 1996 she began her publishing career in New York City at Scientific American. Subsequently she moved to Washington, D.C., to join the staff of National Geographic (first as an assistant art director–researcher hybrid and then as a designer), spent four years as a freelance science communicator and returned to Scientific American in 2007. Christiansen presents and writes on topics ranging from reconciling her love for art and science to her quest to learn more about the pulsar chart on the cover of Joy Division's album Unknown Pleasures. She holds a graduate certificate in science communication from the University of California, Santa Cruz, and a B.A. in geology and studio art from Smith College. Follow Christiansen on X (formerly Twitter) @ChristiansenJen

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